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α-单月桂酸甘油酯对免疫系统的影响

时间:2019-04-18 09:41来源:未知 作者:admin 点击:

01
 

Why is this so important?

为什么这个如此重要?

Korver(2006):

“In general, activation of the immune system decreases performance of modern poultry.To maximize production efficiency, the immune system should be kept in  surveillance mode unless activation is required.“

Korver(2012):

“From a survival standpoint, it is preferable to  alter metabolism from growth towards elimination of the  pathogen.”

Niewold(2010):

“Inflammation whether or not it results from  stress or disease is inversely related to growth. Therefore, research in feed should focus on anti-inflammatory  compounds and anti-inflammatory feed composition.

KEEP THE IMMUNE SYSTEM IN SURVEILLANCE

MODE UNLESS ACTIVATION IS REQUIRED

- - - -

NUTRITIONAL IMMUNOMODULATION

Korver (2006):“一般来说,免疫系统的激活会降低现代家禽的生产能力。为了最大限度地提高生产效率,除非需要激活,否则免疫系统应保持监视模式”。

Korver (2012):“从生存的角度来看,最好是将代谢从生长转变为消除病原体”

Niewold (2010):“炎症是否由压力或疾病引起,与生长成反比。因此,饲料研究应着眼于抗炎化合物和抗炎饲料成分

保持免疫系统监测模式

除非需要激活

- - - -

营养免疫调节

02
 

Innate immunity vs. Adaptive immunity

先天免疫与适应性免疫

03
 

Nutritional immunomodulation of innate immunity

先天免疫的营养免疫调节

Costs for growth:inflammation 10-30%

INNATE IMMUITY

Metabolism of the innate immune cells  themselves does not require much nutrients, but an inflammatory response can be  nutritionally costly.

◆Inflammatory response

◆Recruit distant immune cells to site of infection 

◆Change metabolism 

◇Increased metabolic rate (fever)  

◇Reduced feed intake 

◇Breakdown of skeletal muscle to support gluconeogenesis and synthesis of acute phase  proteins in the liver

生长成本炎症10-30%

先天免疫

先天免疫细胞本身的新陈代谢不需要太多营养,但炎症反应可能会需要很多营养

◆炎症反应

◆将远处的免疫细胞募集到感染部位

◆改变新陈代谢

◇代谢率增加(发烧)

◇减少采食量

◇骼肌的分解,以支持肝脏中糖异生和合成急性期蛋白质

04
 

Nutritional immunomodulation of adaptive immunity

适应性免疫的营养免疫调节

Costs for growth:Antibodies up 3%

ADAPTIVE IMMUNITY

Minimal effect on energy and nutrient requirements of the bird, because the nutrients  used for antibody production and expansion of B cell population is minimal.

Nutritional immunomodulation of adaptive immunity therefore generally targets antibody  production.

生长成本:抗体高达3%

适应性免疫

◆ 对鸟类的能量和营养需求的影响最小,因为用于抗体产生和B细胞群扩增的营养物是最小的

◆因此,适应性免疫的营养免疫调节通常针对抗体的产生

05
 

Results nutritional immunomodulation

产生营养免疫调节

目前我们知道什么?

Anti-inflammatory effect

抗炎作用

Increasing antibody levels (trial 1)

Higher titer =Higher amount of antibodies against IB = Indication of increased immune response

提高抗体水平(试验1).

更高滴度=针对IB的抗体量更高=表明免疫应答增加

Increasing antibody levels (trial 2)

提高抗体水平(试验2)

Increasing antibody levels (trial 3)

A) Lincomycin @ 120 gram / ton feed

B)  No AGP, no additives

C)  FRA®  C12 Liquid: 1 kg / 1000 L

D)  FRA®  C12 Liquid: 2 kg / 1000 L

提高抗体水平(试验3)

A)  林可霉素@ 120克/吨饲料

B)  没有抗生素生长促进剂,没有添加剂

C)  FRA®C12液体:1 kg / 1000 L.

D)  FRA®C12液体:2 kg / 1000 L

No negative effect on IB vaccination efficacy:

 Good vaccine uptake (qPCR)

 No IB relevant lesions or symptoms in challenge trial

◆ 对IB疫苗接种效果无负面影响

◆ 疫苗摄取良好 (qPCR)

◆ 在攻击试验中没有IB相关病变或症状

Modulating IFN-γ

Interferon-gamma (IFN-γ) is a cytokine that plays an  important role in inducing and modulating a series  of immune responses.

Increasing IFN-γ expression might be an effective  approach against a viral infection in broiler chickens.  (Bhagat et al., 2007)

◆调节IFN-γ

◇干扰素-γ(IFN-γ)是一种细胞因子,在诱导和调节一系列免疫反应中起重要作用。

◇增加IFN-γ表达可能是对抗肉鸡病毒感染的有效方法。(Bhagat等,2007)

 

结论

Based on the reduction in NO production an  anti-inflammatory effect of α-monolaurin is  expected.

Based on significant higher IB titer values  found in different trials, α-monolaurin seemed  to improve the immune response.

No negative effect on vaccine uptake.

Based on the significant higher INF-γ level,  FRA® C12 Dry seemed to stimulate the  activity of the immune system.

◆基于NO产生的减少,α-单月桂酸甘油酯的抗炎作用是可以预料的

 基于在不同试验中发现的更高的IB滴度值,α-单月桂酸甘油酯似乎改善了免疫应答

 对疫苗吸收没有负面影响

 基于显着较高的INF-γ水平,FRA®C12Dry似乎刺激了免疫系统的活性

06

Immune response to PRRS, are there possibilities for immunomodulation?

 对蓝耳的免疫应答,是否有免疫调节的可能性?

P-PRRSV: ↑ IL-1, IL-6, IL-10

But we need to control these pro-inflammatory cytokines

高致病性猪繁殖与呼吸综合征:↑ IL-1, IL-6, IL-10

但我们需要控制这些促炎细胞因子

07
 

Immune response to PRRS, are there possibilities for immunomodulation?

对蓝耳的免疫应答,有免疫调节的可能性吗?

It has been implied that stimulating the innate  immunity is more likely to induce protection in pigs  against PRRSV. Therefore, immunomodulation is of  interest, but very complex as PRRSV itself is definitely  an immunomodulator (e.g.suppression of IFN  responses).

Three aims should be considered within an immunomodulation strategy:

◆ To maintain the homeostatic regulatory functions of IFNs during PRRSV infection.

◆ To antagonize the PRRSV-drive amplification of the inflammatory response to LPS. (secondary infections)

◆ To boost antiviral innate immunity

这表明,刺激先天免疫更有可能诱导保护猪对抗PRRSV。因此,免疫调节是有意义的,但非常复杂,因为PRRSV本身绝对是一种免疫调节剂(例如抑制干扰素IF反应)。

在免疫调节策略中应考虑三个目标:

◆  在PRRSV感染期间维持IFN的稳态调节功能

◆  对抗PRRSV驱动脂多糖的炎症反应的放大。(继发感染)

◆  增强抗病毒先天免疫力

08
 

 

How does alpha-monolaurin works against PRRS?

α-单月桂酸甘油酯是如何对抗蓝耳的呢?

COLLABORATION WITH GD ANIMAL HEALTH TO GET MORE ANSWERS!

GD动物健康部合作获得更多答案!

 

来源:荷兰FRAmelco/佰高威盛公司

声明:本文为“华康动物健康服务平台”所有,未经许可,禁止转载!谢谢合作

来都来了,点个在看再走吧~~~

 
 
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